You’ve probably been exposed to one news headline or another in the recent past (let’s say the last 5 years) that reads something like “SCIENTISTS DISCOVER GENES THAT CAUSE (X).” X, of course, varies massively based on the study itself (and sometimes the bastardisation of said study by media): it can include describing medical conditions such as cancer, autism or congenital diseases; behavioural traits, such as sexual preferences; or broad physical traits, such as the classic problem of the inheritability of height. Unsurprisingly, you may think that trying to find the genes responsible for some traits should be either a) super easy, or b) super hard, depending on your own philosophical preference or the trait in question. So how do these studies come about, anyway?
This is based on the idea that for genes that are not related to traits under selection (either positively or negatively), new mutations should be acquired and lost under predominantly random patterns. Although this accumulation of mutations is influenced to some degree by alternate factors such as population size, the overall average of a genome should give a picture that largely discounts natural selection. But is this true? Is the genome truly neutral if averaged?
First, let’s take a look at what we mean by neutral or not. For genes that are not under selection, alleles should be maintained at approximately balanced frequencies and all non-adaptive genes across the genome should have relatively similar distribution of frequencies. While natural selection is one obvious way allele frequencies can be altered (either favourably or detrimentally), other factors can play a role.
The extent of this linkage effect depends on a number of other factors such as ploidy (the number of copies of a chromosome a species has), the size of the population and the strength of selection around the central locus. The presence of linkage and its impact on the distribution of genetic diversity (LD) has been well documented within evolutionary and ecological genetic literature. The more pressing question is one of extent: how much of the genome has been impacted by linkage? Is any of the genome unaffected by the process?
Although I avoid having a strong stance here (if you’re an evolutionary geneticist yourself, I will allow you to draw your own conclusions), it is my belief that the model of neutral theory – and the methods that rely upon it – are still fundamental to our understanding of evolution. Although it may present itself as a more conservative way to identify adaptation within the genome, and cannot account for the effect of the above processes, neutral theory undoubtedly presents itself as a direct and well-implemented strategy to understand adaptation and demography.